Fri May 20 2022

69 articles - From Friday May 13 2022 to Friday May 20 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Evolving Practice Choices by Newly Certified and More Senior General Internists : A Cross-Sectional and Panel Comparison.

Newly certified general internists are largely choosing hospital medicine as their career choice whereas more senior physicians increasingly see patients only in the outpatient setting. Primary funding source This study did not receive direct funding.

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Human Papillomavirus Vaccine Impact and Effectiveness Through 12 Years After Vaccine Introduction in the United States, 2003 to 2018.

Nationally representative data show increasing impact of the vaccination program and herd protection. Vaccine effectiveness estimates will be increasingly affected by herd effects. Primary funding source Centers for Disease Control and Prevention.

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Lancet

The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial.

Interpretation The results of this randomised trial establish the benefit of adding short-term ADT to PBRT to prevent progression in prostate cancer. To our knowledge, these are the first such findings to show that extending salvage radiotherapy to treat the pelvic lymph nodes when combined with short-term ADT results in meaningful reductions in progression after prostatectomy in patients with prostate cancer. Funding National Cancer Institute.

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N Engl J Med

Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma.

The risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 µg of albuterol and 160 µg of budesonide than with as-needed use of albuterol alone among patients with uncontrolled moderate-to-severe asthma who were receiving a wide range of inhaled glucocorticoid-containing maintenance therapies. (Funded by Avillion; MANDALA ClinicalTrials.gov number, NCT03769090.).

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Results of Two Cases of Pig-to-Human Kidney Xenotransplantation.

Genetically modified kidney xenografts from pigs remained viable and functioning in brain-dead human recipients for 54 hours, without signs of hyperacute rejection. (Funded by Lung Biotechnology.).

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Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis.

In this placebo-controlled trial, treatment with BI 1015550, either alone or with background use of an antifibrotic agent, prevented a decrease in lung function in patients with idiopathic pulmonary fibrosis. (Funded by Boehringer Ingelheim; 1305-0013 ClinicalTrials.gov number, NCT04419506.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Addressing Inequities in SARS-CoV-2 Vaccine Uptake: The Boston Medical Center Health System Experience.

Mobile vaccination events were key in reaching younger people living in locations with the highest SVIs. Challenges included the need for a robust operational infrastructure and mistrust of the health system given the long history of economic disinvestment in the surrounding community. The BMC model could serve as a blueprint for other medical centers interested in implementing programs aimed at increasing vaccine uptake during a pandemic and in developing an infrastructure to address other health-related disparities.

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Promoting Safety, Transparency, and Quality in Xenotransplantation.

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Lancet

Offline: Bill Gates and the fate of WHO.

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Why Roe v. Wade must be defended.

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N Engl J Med

Audio Interview: What to Make of Covid-19 Hot Spots.

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Brain Tumors in Children.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Capitalism, not racism.

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Decolonising global health: a Philippine perspective.

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The truth about decolonising global health worth spreading.

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Tobacco control: getting to the finish line.

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Tobacco harm reduction matters.

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Tofacitinib for juvenile idiopathic arthritis - Authors' reply.

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Tofacitinib for juvenile idiopathic arthritis.

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Yes, democracy is good for our health-but which democracy?

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N Engl J Med

Marginal-Zone Lymphomas.

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Marginal-Zone Lymphomas.

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Marginal-Zone Lymphomas. Reply.

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Neutralization of the SARS-CoV-2 Deltacron and BA.3 Variants.

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Nivolumab in Esophageal Squamous-Cell Carcinoma.

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Nivolumab in Esophageal Squamous-Cell Carcinoma.

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Nivolumab in Esophageal Squamous-Cell Carcinoma.

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Nivolumab in Esophageal Squamous-Cell Carcinoma. Reply.

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Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults.

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Protection by a Fourth Dose of BNT162b2 against Omicron in Israel.

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Protection by a Fourth Dose of BNT162b2 against Omicron in Israel. Reply.

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SER-109 for Recurrent Clostridioides difficile Infection.

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SER-109 for Recurrent Clostridioides difficile Infection.

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SER-109 for Recurrent Clostridioides difficile Infection. Reply.

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Use of a Drone-Delivered Automated External Defibrillator in an Out-of-Hospital Cardiac Arrest.

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Use of eFAST in Patients with Injury to the Thorax or Abdomen.

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Use of eFAST in Patients with Injury to the Thorax or Abdomen. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion.

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Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion.

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Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion.

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Annals for Educators - May 2022.

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Annals for Hospitalists - May 2022.

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Long-Term Effectiveness of Human Papillomavirus Vaccination: Implications for Future Reduction in Cancer.

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Matter Over Mind.

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Web Exclusive. Annals Consult Guys - Physical Examination During Telemedicine Visits.

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Web Exclusive. Annals for Hospitalists Inpatient Notes - COVID-19, Hospital Medicine, and a Way Forward.

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Web Exclusive. Annals On Call - Evidence-Based Care of Substance Use Disorders.

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Lancet

Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome.

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After the Ockenden review: a chance to reset maternal and perinatal care in the UK?

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Calls to restart testing for parasitic disease at US CDC.

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Effective post-pandemic governance must focus on shared challenges.

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Health organizations fear effects of US abortion ruling.

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Luc Antoine Montagnier.

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Migrant traumas heard.

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Prevention of conflict-related sexual violence in Ukraine and globally.

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Raj Panjabi: bringing a global outlook to the US pandemic response.

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Researcher trauma: when our stories collide.

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Responding to the Ukraine refugee health crisis in the EU.

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Zero COVID in China: what next?

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N Engl J Med

Case 15-2022: A 57-Year-Old Man with Persistent Cough and Pulmonary Opacities.

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Catching Up on REMs.

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Gaucher's Disease.

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Institutionalizing Misinformation - The Dietary Supplement Listing Act of 2022.

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Long-Term Care in the United States - Problems and Solutions.

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Only Halfway There with Sudden Infant Death Syndrome.

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Physicians Spreading Misinformation on Social Media - Do Right and Wrong Answers Still Exist in Medicine?

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Progress toward Pig-to-Human Xenotransplantation.

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Reforming Nursing Home Financing, Payment, and Oversight.

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Syphilitic Aortitis.

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